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Publication in Organic Process Research & Development

TAKASAGO has published a paper entitled " Highly Efficient and Selective Hydrogenation of Sugars Catalyzed by Ru-MACHO-BH: Practical Synthesis of Sugar Alcohols " in Organic Process Research & Development.


 Org. Process Res. Dev.  202226, 5, 1442–1449.


The development of an efficient synthetic route for sugar alcohols is described. A highly efficient synthesis of sugar alcohols was achieved by selective hydrogenation with a homogeneous catalyst. Ru-MACHO®-BH promoted the hydrogenation with extremely high reactivity and selectivity. The reaction could be applied to various kinds of mono- and disaccharides, and this is the first report of highly selective synthesis of disaccharides.