Fine Chemicals

Pioneering in catalytic asymmetric isomerization reactions, Takasago International successfully manufactured the l -menthol by utilizing the chiral ligand BINAP. Processes using BINAP permitted as well to improve asymmetric hydrogenation of carbonyl compounds.
Furthermore, as drugs effectiveness frequently depends on their stereochemistry, use of such techniques provides excellent results in the medical field. We could efficiently extend these chemical processes to the manufacture of pharmaceutical intermediates and antibacterial agents such as antibiotics.
Nowadays BINAP have been used extensively leading to successful improvements of chemical reactions efficiencies, to reduce their by-products wastes, and definitely allows an elegant integration of our chemistry to the environmental-friendly practices.

In addition, our efforts for innovating catalysis of asymmetric hydrogenation ligands gave birth to the brand-new, original SEGPHOS®.
In harmony with our spirit for developing green-chemistry and for contributing to the construction of a sustainable society, we are performing excellently in reducing esters through hydrogenation reactions catalyzed by Ru-MACHO®, key to tremendously reduce large amount of wastes and energy requirements necessary for conventional chemical reduction methods.

Recently we could develop the novel ligand BRIDP® and combined a coupling reaction catalyzed by Palladium. This latter reaction led to the Nobel Prize in Chemistry 2010 jointly awarded to Richard F. Heck, Ei-ichi Negishi and Akira Suzuki for the palladium-catalyzed cross couplings in organic synthesis.
We are developing organic photoconductors (OPCs) by arylamination with this ligand. We are now considering extending the coupling reactions to manufacture pharmaceutical intermediates.

SEGPHOS, Ru-MACHO and BRIDP are registered trademarks or trademarks of Takasago International Corporation in Japan and other countries.