触媒技術

当社の触媒・配位子に関する技術は、四半世紀にわたる絶え間ない努力と数々の経験に裏打ちされたもので、私たちは不斉水素化反応のほかにも様々な反応について特許を有しています。自社でのプロセス検討や製造において当社の触媒・配位子を活用することを望まれるお客様はこれらの知的財産をご利用いただくことができるとともに、プロセス開発や受託製造を当社で行なうオプションも用意しています。
技術資料「Technical Information」と「Ligand and Catalyst Guide」がお客様の有機化学合成に役立つことを願っています。製品と同様、私どもの技術についても当社ファインケミカル事業本部までお気軽にお問い合わせください。

技術資料

Technical Information [pdf]
Ligand and Catalyst Guide [pdf]
Procedure of Asymmetric Hydrogenation Reactions [pdf]
Procedure of Asymmetric Transfer Hydrogenation Reactions [pdf]
Typical Procedure of Transesterification with ZnTAC24 [pdf]
Typical Procedure of Hydrogenation Using Ru-MACHO [pdf]

Technical Information

Index
1. Asymmetric Hydrogenation
1.1 Classical Hydrogenation
1.1.1 Functionalized ketones
a. β-Ketoesters
b. α-Ketoesters
c. γ-Ketoesters
d. Hydroxyacetones & Amino ketones
e. 1.3-Diketones
f. Keto sufonates & Keto phosphonates
g. Dynamic Kinetic Resolution
1.1.2 Imines
1.1.3 Olefins
a. α,β-Uunsaturated Carboxylic Acids
b. Itaconic acid delivatives
c. Allyl alcohols
d. α,β-Unsaturated lactones
e. Diketene & Methylene-γ-butyrolactone
f. Dehydro amino acids
g. Enamides h. Enamino esters
1.2 Direct Reductive Amination
1.3 RuCl2(diphosphine)(diamine) catalyzed Hydrogenation
a. Aryl alkyl ketones & Heteroaryl alkyl ketones
b. Aryl aryl ketones
c. Others
d. Dynamic Kinetic Resolution
2. Asymmetric Isomerization
3. Monophosphine Ligands for Pd catalyzed Coupling Reactions
3.2 Suzuki-Miyaura Reaction
4. Other Reactions
4.1 Cyanomethylation
4.2 Vinylation & Phenylation
4.3 Fluorination
4.4 Aza-Michael addition
4.5 Asymmetric alcoholysis of azlactone
4.6 Cyclotrimerization of terminal alkynes
5. Publications

Ligand and Catalyst Guide

Takasago Catalyst - Decision Tree-
Ketone to Alcohol
Ketone to Amine
Olefin to Alkane
Allylamine to Aldehyde
Buchwald-Hartwig Reaction
Suzuki-Miyaura Reaction
Vinylation and Arylation
Cyanomethylation
Fluorination
Hydrosilylation

General Procedure

Procedure of Asymmetric Hydrogenation Using Diphosphine-Ruthenium Complex
Procedure of Asymmetric Transfer Hydrogenation Using Ruthenium Complex
Typical Procedure of Transesterification with ZnTAC24
Typical Procedure of Hydrogenation Using Ru-MACHO