Asymmetric Hydrogenation

At Takasago International Corporation, we consider Asymmetric Hydrogenation one of our core technologies. In addition to contract manufacturing of API GMP intermediates, optically active compounds and other fine chemicals, we offer supply of catalysts and ligands and license out technology, These all stem from our expertise in the field of asymmetric hydrogenation.

Contract Manufacturing

We have been a pioneer in installing high-pressure hydrogenation facilities capable of maximizing asymmetric hydrogenation performance. Our high-pressure hydrogenation facilities have been recognized to be among the finest in the world, and we have a rigorous regime in place to guarantee the quality of the optically active compounds produced while ensuring regulatory compliance.


Hydrogenation Equipment
Equipment Material Volume Number Pressure
Autoclave Hastelloy 0.1m3 1 10MP
1m3 1 10MP
3.5m3 1 5MP
10m3 1 5MP
Stainless Steel 2m3 1 3MP
3.5m3 1 3.5MP
5m3 1 5MP
7m3 1 3MP
10m3 1 3MP
10m3 1 5MP
Pipe Flow Reactor(PFR) Stainless Steel 0.1m3 1 5MP
0.2m3 1 5MP

Manufacture and sale of catalysts and ligands

Our catalysts and ligands are sold as reagents in small quantities through Strem Chemicals, Sigma-Aldrich and Tokyo Chemical Industry. Supplies in the large scale, anywhere from the kilogram to the hundred kilogram scale, are sold directly by us. Takasago also offers quality assurance and provides procedural guidelines for utilizing catalysts and ligands efficiently. We use these ligands and catalysts in our processes and hence we ensure that the clients are able to achieve the same level of quality on their production site as we achieve on ours.

Licensing of technology

Our patents are not limited to those for asymmetric synthesis but to numerous other reactions as well. These range from patents for catalysts and ligands to process patents. Takasago would like to provide clients with access to the patents. Please contact us for details.

Contract research

The unrivaled knowledge and know-how we have built up over the decades has given us the edge as the experts in asymmetric hydrogenation. This specialized knowledge enables our experienced research staff to optimize various production processes. We have ensured that the processes developed by Takasago would be able to be recreated and scaled up at scale at the client’s own production site and plan to continue this practice in moving forwards.