Takasago’s ligand and catalyst technologies are based on continuous efforts and numerous experiences over a quarter century. Please feel free to access our tehcnologies as well as products! We hope the following documents will help you achieve your chemistry. Technical Documents Technical Information Ligand and Catalyst Guide Procedure of Asymmetric Hydrogenation Reactions Procedure of Asymmetric Transfer Hydrogenation Reactions Technical Information Index 1. Asymmetric Hydrogenation 1.1 Classical Hydrogenation 1.1.1 Functionalized ketones a. β-Ketoesters b. α-Ketoesters c. γ-Ketoesters d. Hydroxyacetones & Amino ketones e. 1.3-Diketones f. Keto sufonates & Keto phosphonates g. Dynamic Kinetic Resolution 1.1.2 Imines 1.1.3 Olefins a. α,β-Uunsaturated Carboxylic Acids b. Itaconic acid delivatives c. Allyl alcohols d. α,β-Unsaturated lactones e. Diketene & Methylene-γ-butyrolactone f. Dehydro amino acids g. Enamides h. Enamino esters 1.2 Direct Reductive Amination 1.3 RuCl2(diphosphine)(diamine) catalyzed Hydrogenation a. Aryl alkyl ketones & Heteroaryl alkyl ketones b. Aryl aryl ketones c. Others d. Dynamic Kinetic Resolution 2. Asymmetric Isomerization 3. Monophosphine Ligands for Pd catalyzed Coupling Reactions 3.1 Buchwald-Hartwig Reaction 3.2 Suzuki-Miyaura Reaction 4. Other Reactions 4.1 Cyanomethylation 4.2 Vinylation & Phenylation 4.3 Fluorination 4.4 Aza-Michael addition 4.5 Asymmetric alcoholysis of azlactone 4.6 Cyclotrimerization of terminal alkynes 5. Publications Ligand and Catalyst Guide Takasago Catalyst - Decision Tree- Ketone to Alcohol Ketone to Amine Olefin to Alkane Allylamine to Aldehyde Buchwald-Hartwig Reaction Suzuki-Miyaura Reaction Vinylation and Arylation Cyanomethylation Fluorination Hydrosilylation General Procedure Procedure of Asymmetric Hydrogenation Using Diphosphine-Ruthenium Complex Procedure of Asymmetric Transfer Hydrogenation Using Ruthenium Complex

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