Takasago has a history of over a quarter century in asymmetric synthesis and our challenge to create new technologies will continue.
|
| 1980 |
Professor Ryoji Noyori’s group developed BINAP catalyst. |
| Asymmetric isomerization of allylamine by Rh-BINAP complex. |
| Asymmetric synthesis of l-menthol. |
| 1983 |
Commercial production of BINAP by optical resolution. |
| The first industrial asymmetric isomerization, l-menthol. |
| 1984 |
Asymmetric hydrogenation of dehydroamino acids by Ru-BINAP complex. |
| 1988 |
Asymmetric hydrogenation of ß-ketoesters by Ru-BINAP complex. |
| 1989 |
Dynamic kinetic resolution. |
| 4-Acetoxy azetidinone, 4-AA process. |
| 1992 |
Commercial production of chiral 1,2-propanediol. |
| 1993 |
Commercial production of 4-AA. |
| 1994 |
Hydroformylation ligands, BINAPHOS and BIPNITE. |
| 1995 |
Noyori reduction, RuCl2(diphosphine)(diamine) system. |
| 1996 |
Asymmetric transfer hydrogenation, RuCl(arene)(sulfonylated diamine) system. |
| SEGPHOS® , advanced-BINAP ligand. |
| 2001 |
Professor Ryoji Noyori, a board member of Takasago, received the Nobel Prize. |
| BRIDP, advanced ligands for Pd-Coupling. |
| 2002 |
Received Molecular Chirality Award, “Development of SEGPHOS”. |
| 2003 |
Reductive amination for ß-amino acid. |
| 2005 |
Cu mediated asymmetric hydrogenation. |
| 2006 |
Received Merck’s Suppliers’ Award. |
| 2007 |
Received Tetrahedron Most Cited Paper 2004-2007 Award, “Recent Advances in Biaryl-Type Bisphosphine Ligands”. |
| Hydrogenation of esters by homogeneous catalyst . |
| 2008 |
Received Tetrahedron Most Cited Paper 2005-2008 Award, “Recent Advances in Biaryl-Type Bisphosphine Ligands”. |
| 2009 |
Received Poster Award at 2009’s OMCOS in Glasgow, “An Efficient Synthesis of Chiral Alcohols via Catalytic Hydrogenation of Esters”. |
